DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia
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چکیده
منابع مشابه
Detection of R882 Mutations in DNMT3A Gene in Acute Myeloid Leukemia: A Method Comparison Study
Background: Somatic mutations in the hotspot region of the DNA-methyltransferase 3A (DNMT3A) gene were recurrently identified in acute myeloid leukemia (AML). It is believed that DNMT3A mutations confer an adverse prognosis for AML patients. These lines of evidence support the need for a rapid and cost-efficient method for the detection of these mutations. The present study aimed to establish h...
متن کاملDNMT3A Mutations in Acute Myeloid Leukemia
Timothy J. Ley, M.D., Li Ding, Ph.D., Matthew J. Walter, M.D., Michael D. McLellan, B.S., Tamara Lamprecht, B.S., David E. Larson, Ph.D., Cyriac Kandoth, Ph.D., Jacqueline E. Payton, M.D., Ph.D., Jack Baty, B.A., John Welch, M.D., Ph.D., Christopher C. Harris, B.S., Cheryl F. Lichti, Ph.D., R. Reid Townsend, M.D., Robert S. Fulton, M.S., David J. Dooling, Ph.D., Daniel C. Koboldt, M.S., Heather...
متن کاملDNMT3A mutations in Chinese childhood acute myeloid leukemia
BACKGROUND DNA methyltransferase 3A (DNMT3A) mutations have been found in approximately 20% of adult acute myeloid leukemia (AML) patients and in 0% to 1.4% of children with AML, and the hotspots of mutations are mainly located in the catalytic methyltransferase domain, hereinto, mutation R882 accounts for 60%. Although the negative effect of DNMT3A on treatment outcome is well known, the progn...
متن کاملEvaluation of the CD123 Expression and FLT3 Gene Mutations in Patients with Acute Myeloid Leukemia
Background and Objective: Identification of cytogenetic and molecular changes plays an important role in acute myeloid leukemia (AML) patients. Thus, they are used in classification, prognosis and treatment of the disease. The CD123 expression and FLT3 gene mutations are also the variations that may assist in prognosis and treatment of patients with AML.Methods:</...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2015
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2015.359